How much weight can you lose on Mounjaro?

Clinical studies provide the most reliable way to understand how much weight people can expect to lose on Mounjaro. The largest study to date is SURMOUNT 1, which followed adults with obesity or overweight for 72 weeks.

In this study, people taking Mounjaro alongside healthy lifestyle changes lost an average of:

• Around 15 percent of their body weight on the 5 mg dose
• Around 19 and a half percent on the 10 mg dose
• Around 21 percent on the 15 mg dose

These are average results. Some people lost more than 25 percent of their body weight, while others lost less. The study also showed that weight loss increased steadily as the dose increased, especially after the 10 mg and 15 mg steps.

SURMOUNT 3, which combined Mounjaro with structured lifestyle support, reported even greater average weight loss. This highlights how important behaviour and habit change are for achieving the best results.

Clinical trials give a helpful benchmark, but real outcomes vary from person to person.

Most people start Mounjaro at a very low dose so that their body can adjust. Because of this gradual approach, weight loss builds over time.

• Weeks 1 to 4: Appetite often reduces quite quickly. Weight change may be small at this stage because the dose is still low.
• Weeks 8 to 12: Changes become more noticeable as you move through the early dose steps.
• Months 3 to 6: Steady weight loss usually continues as you reach the mid to higher doses.
• Months 6 to 12 and beyond: Weight loss adds up gradually. Many people reach the largest changes after several months of consistent use.

Individual patterns vary. Some people respond early, others notice larger drops later in treatment.

People respond differently to Mounjaro. Several factors influence how much weight you may lose.

Starting weight and BMI
People with a higher starting weight often see larger absolute changes, although the percentage changes are similar across groups.

Dose and escalation speed
Moving through the dose steps is important for reaching the levels used in clinical trials. If side effects slow your escalation, your overall weight loss may be lower or take longer.

How consistently you take it
Regular weekly dosing helps keep the medication working at its full effect.

Side effects and tolerance
Some people experience nausea or reduced appetite that helps weight loss. Others find side effects limit their ability to increase the dose.

Eating patterns and behaviours
Habits around snacking, convenience foods, emotional eating, or portion size make a large difference. Combining Mounjaro with behaviour change gives better results.

Activity and muscle mass
Being active supports muscle, metabolism, and long term progress.

Sleep and stress
Poor sleep and high stress levels can increase hunger hormones and may reduce weight loss.

These factors help explain why two people on the same dose can see different results.

Everyone starts Mounjaro at 2.5 mg. This is not designed for weight loss but for helping your body adjust. The dose then increases gradually every four weeks if you tolerate it. Higher doses tend to produce greater weight loss.

A typical progression is:

2.5 mg → 5 mg → 7.5 mg → 10 mg → 12.5 mg → 15 mg

Many people reach a strong response between 7.5 mg and 10 mg. Some need 12.5 mg or 15 mg to reach the levels seen in trials. If you remain on lower doses for longer because of side effects, your total weight loss may be lower or simply take more time.

Everyone escalates at their own pace, and slower escalation is often advised if you experience nausea or digestion symptoms.

Even before the numbers on the scales move, people commonly report:

• Feeling full sooner during meals
• Fewer cravings or reduced snacking
• Less interest in high calorie foods
• More stable energy between meals
• Smaller portion sizes without effort

Visible changes often follow as you reach the mid to higher doses. Clothes may fit differently, appetite feels more controlled, and mealtime habits begin to shift naturally.

Patterns from research and real world use show some variation:

People who often lose more:

• Those with insulin resistance or prediabetes
• People who previously struggled with hunger or cravings
• People who combine treatment with behaviour change
• Individuals who reach the higher doses without issues

People who may lose less:

• Those who stay on the lower doses for longer
• People who already eat a very low calorie diet
• People with limited ability to increase activity
• Those with disrupted sleep or high stress levels
• People whose appetite was already low before starting

This variation is normal and reflects differences in biology, lifestyle, and how quickly someone can move through the dose steps.

Mounjaro works best when paired with healthy routines. Small, consistent changes add up over time.

• Aim for balanced meals with enough protein
• Stay hydrated throughout the day
• Avoid skipping meals
• Add movement you enjoy, such as walking or light strength training
• Plan snacks and meals to reduce impulsive eating
• Prioritise sleep
• Manage stress where possible
• Seek help for behaviours like emotional eating, grazing, or cravings

These habits improve hunger control, support muscle, and help you achieve results closer to the clinical trial averages.

Safe and effective weight management requires a careful clinical process. Every treatment decision is based on your health, medical history, and individual needs. Your assessment is reviewed by GMC registered clinicians, and prescribing is supported by The Independent Pharmacy. Our clinical team focuses on helping you make steady progress with personalised advice, regular support, and clear information about the risks and benefits.

Key points that guide your care:

• UK regulated service
• Individual assessment before any treatment decisions
• Clinician reviewed educational content
• Support for healthy behaviour change

Mounjaro works by helping you feel fuller and reducing appetite, but long term results are shaped just as much by your routines around food, movement, sleep, and stress. Understanding your eating patterns can make a significant difference to how your body responds.

If you want to explore specific habits that affect weight loss, you can read more about:

• Snacking between meals
• Eating late at night
• Eating when not hungry
• Secret eating
• Portion control
• Mindless eating
• Grazing
• Craving sugar
• Comfort eating
• Emotional eating

If you would like to explore more detailed information about Mounjaro and GLP 1 treatments, these guides provide clear and balanced explanations:

• How Mounjaro works
• Mounjaro dosage guide
• Mounjaro side effects (and how to manage them)
• Wegovy vs Mounjaro
• GLP 1 weight loss injections guide
• Weight loss medications guide
• Exercise and GLP 1 medications
• Healthy eating on GLP 1 medications

If you want to understand whether treatment may be suitable for your health needs, you can complete a short assessment. A clinician will review your information and explain the options available, based on your medical history and personal goals.

Take the assessment here.

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other healthcare professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire alongside other independently validated medical information about you and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases, the clinicians may contact you for additional information. See Terms of Service for more information.