Supplements and GLP-1s: what you might need and why

When taking GLP-1 medication such as Mounjaro or Wegovy, your appetite and digestion naturally change. Eating less can make it harder to get enough vitamins and minerals from food alone, particularly if you’re also experiencing nausea or smaller portion sizes.

This guide explains which supplements may be helpful for people using GLP-1 receptor agonists, how to take them safely, and when to seek professional advice before starting anything new.

GLP-1 receptor agonists can reduce calorie and nutrient intake by slowing digestion and enhancing fullness. Over time, this may lead to mild deficiencies if your diet lacks variety or volume.

Commonly affected nutrients include:

• Vitamin B12, important for energy and nerve health
• Iron, which supports oxygen transport and reduces fatigue
• Vitamin D, needed for bone and immune health
• Calcium, especially if dairy intake is low
• Electrolytes, which can become imbalanced if hydration is poor

Prioritise food first

Whole foods should remain your main source of nutrients. Focus on lean proteins, fruit, vegetables, and fortified foods before turning to supplements.

Consider a daily multivitamin

A simple once-daily tablet covering B12, iron, vitamin D, and calcium can support most people using GLP-1s. Avoid high-dose formulations unless prescribed.

Use Vitamin D all year round

The NHS recommends vitamin D for adults, especially in the UK where sunlight exposure is limited.

Maintain iron levels

Women and those eating smaller meals may need additional iron. Pair iron-rich foods (lentils, spinach, fortified cereals) with vitamin C to enhance absorption.

Support gut health

If constipation or nausea persist, a probiotic supplement may help restore balance, though results vary.

Challenge: Nausea from tablets
Practical Response: Take supplements with food or a small snack rather than on an empty stomach.

Challenge: Constipation from iron
Practical Response: Choose gentle iron formulations or liquid options and increase fluid intake.

Challenge: Over-supplementing
Practical Response: Avoid multiple overlapping products; too much of certain vitamins can be harmful.

Challenge: Difficulty swallowing tablets
Practical Response: Use chewable or liquid forms if available.

Time: Morning
Supplement: Multivitamin with breakfast
Tip: Choose one suitable for adults with balanced doses.

Time: Midday
Supplement: Vitamin D (if not included above)
Tip: Take with food containing fat.

Time: Evening
Supplement: Iron or calcium (if prescribed)
Tip: Space from other minerals for better absorption.

Contact a Medicspot clinician if you:

• Feel persistently tired, dizzy, or light-headed
• Experience tingling or weakness in your hands or feet
• Struggle to eat a varied diet or tolerate supplements
• Are unsure which products are appropriate for your treatment

Our clinicians can review your diet, medication, and lab results to tailor safe, effective supplement advice.

Medicspot’s clinicians and nutrition experts provide personalised guidance to ensure your diet and supplements work safely alongside GLP-1 treatment. Whether you need help choosing a multivitamin or managing side effects, our team ensures you stay healthy and supported throughout your journey.

Take our free online assessment to see if GLP-1 treatment could be right for you, or use the weight loss calculator below to find out instantly if you are likely to be eligible and to see how much weight you could lose.

Weight loss supplements can be a helpful addition to your weight loss journey, but they should be used with caution and in conjunction with healthy lifestyle habits.

By understanding the different types of supplements, their mechanisms, benefits, and risks, you can make informed decisions about which products are right for you.

Always consult with a healthcare provider before starting any new supplement, and focus on long-term, sustainable weight loss strategies for the best results.

With the right approach, weight loss supplements can support your efforts to achieve a healthier, more fulfilling life.

Disclaimer

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases the clinicians may contact you for additional information. See our Terms of Service for more information.