Mounjaro Results: What to Expect and How Much Weight You Can Lose

Most people using Mounjaro as part of a structured weight loss plan lose a significant amount of weight over time.

In clinical trials:

• People taking higher doses of Mounjaro lost on average ~15 -20% percent of their starting body weight over 72 weeks.
• Appetite changes usually begin in the first few weeks.
• Visible weight loss often starts between weeks 4 and 8.
• The largest changes are usually seen between months 3 and 12.

Clinical trials (including SURMOUNT-1) and real Medicspot user data (sample size 1,029; Autumn 2024 to Spring 2025) provide the following Mounjaro weight loss results data:

• Month 1 – Mounjaro dose 2.5mg
  • Clinical trial data: N/A (starting dose to check tolerance)
  • Medicspot real user data: average month 1 weight loss = 3.4kg (7.5lbs)
• Month 2 – Mounjaro dose 5mg
  • Clinical trial data: average weight loss 6%
  • Medicspot real user data: average month 2 weight loss = 6.1kg (13.4lbs)
• Month 3 – Mounjaro dose 7.5mg
  • Clinical trial data: average weight loss 9%
  • Medicspot real user data: average month 3 weight loss = 7.5kg (16.4lbs)
• Month 4 – Mounjaro dose 10mg
  • Clinical trial data: average weight loss 11%
  • Medicspot real user data: average month 4 weight loss = 9.5kg (20.9lbs)
• Month 5 – Mounjaro dose 12.5mg
  • Clinical trial data: average weight loss 12%
  • Medicspot real user data: average month 5 weight loss = 12.5kg (27.6lbs)
• Month 6 – Mounjaro dose 15mg
  • Clinical trial data: average weight loss 16.5%
  • Medicspot real user data: average month 6 weight loss = 14.2kg (31.3lbs)

In clinical studies, people taking the higher doses of Mounjaro lost on average around 15 to more than 20 percent of their starting body weight after about 72 weeks of treatment, when used alongside lifestyle changes.

Not everyone reaches the highest dose, and not everyone will see the same level of response. Some people will lose less than the average, and some will lose more.

The data below gives an approximate overview of what was seen in studies. These are ranges, not targets.

Everyone follows their own journey, but many people recognise the broad pattern below. The doses and timing described are typical titration steps and may be adjusted by your prescriber.

We analyzed data from patients after their first month (4 weekly doses) of Mounjaro. Here’s what we found:

• Dose = 2.5mg (this is the starting dose for all patients)
• Sample size: 1029 patients
• Average 1 month weight loss (all patients) = 3.4kg (7.5lbs)

Patients who combined Mounjaro with mindful eating and light physical activity tended to see higher results – as did those who engaged with the Medicspot behaviour change course and weekly whatsapp check-ins with a Medicspot Health Coach.

Mounjaro Month 1 Tips and Insights

• Diet: Those who adopt lower-calorie or protein-rich diets typically see faster progress.
• Exercise: Even mild activity like walking supports weight loss.
• Consistency: Missing doses or overeating can affect results.
• Engagement: patients engaging with the Medicspot behaviour change course and weekly whatsapp check-ins with a Medicspot Health Coach generally see more effective weight loss.

Want to make the most of your first month on Mounjaro? Here are some actionable tips:

• Stick to your dosing schedule
• Keep a food and symptom journal
• Prioritize hydration and fiber-rich foods
• Set realistic goals and track your progress
• Join a support community for encouragement

We analyzed data from patients after their first 2 months (8 weekly doses) of Mounjaro. Here’s what we found:

• Dose = either 2.5mg or 5mg (2.5mg is the starting dose for all patients)
• Sample size: 1029 patients
• Average weight loss after 2 months (all patients) = 6.1kg (13.4lbs)

Most users reported a noticeable acceleration in results compared to month one, especially those who transitioned to 5 mg. Several also highlighted improved energy levels and motivation.

Mounjaro Month 2 Tips and Insights

Your outcomes after 8 weeks can depend on:

• Dose progression: Most see stronger effects after increasing to 5 mg
• Adherence: Skipped doses or inconsistent routines may delay results
• Lifestyle changes: Improvements in diet, hydration, and movement amplify Mounjaro’s impact
• Side effect management: Those who adapted better in month one tend to sustain progress more easily
• Engagement: patients engaging with the Medicspot behaviour change course and weekly whatsapp check-ins with a Medicspot Health Coach generally see more effective weight loss.

Want to make the most of your first 2 months on Mounjaro? Here are some actionable tips:

• Reassess your nutrition plan and adjust if needed
• Build in a consistent activity routine
• Stay ahead of side effects (hydration, rest, light meals)
• Track not just weight, but energy, hunger, and habits
• Don’t compare your pace to others: consistency wins!

We analyzed data from patients after their third month (12 weekly doses) of Mounjaro. Here’s what we found:

• Dose = most commonly 7.5mg
• Sample size: 1029 patients
• Average weight loss after 3 months (all patients) = 7.5kg (16.4lbs)

Most users reported a noticeable acceleration in results compared to month one, especially those who transitioned to 5 mg in month 2 and 7.5mg in month 3. Several also highlighted improved energy levels and motivation.

Mounjaro Month 3 Tips and Insights

Your progress after 12 weeks can depend on:

• Dosage: Most see enhanced appetite control at 7.5–10 mg
• Lifestyle habits: Meal prep, water intake, and movement all compound effects
• Support systems: Many users find success with peer support or coaching
• Mindset: A long-term, habit-focused approach tends to be more sustainable than a purely weight-focused one.
• Engagement: patients engaging with the Medicspot behaviour change course and weekly whatsapp check-ins with a Medicspot Health Coach generally see more effective weight loss.

Want to make the most of your first 3 months on Mounjaro? Here are some actionable tips:

• Refresh your goals to stay motivated
• Keep logging meals, symptoms, and milestones
• Try new, sustainable activity (walking, yoga, strength training)
• Be flexible with your approach while maintaining consistency
• Share your experience: it helps others and reinforces your journey

We analyzed data from patients after their fourth month (16 weekly doses) of Mounjaro. Here’s what we found:

• Dose = most commonly 7.5mg or 10mg
• Sample size: 1029 patients
• Average weight loss after 2 months (all patients) = 9.5kg (20.9lbs)

Weight loss continued for the majority, though a few experienced plateaus. These are often overcome through routine adjustments or dose evaluation.

Mounjaro Month 4 Insights and Tips

Progress continues between 12 and 16 weeks, and may be shaped by:

• Dose stability: 10 mg tends to show the strongest appetite control
• Mental fatigue: It’s normal to feel less excited—structure helps
• Plateau phases: Reassess calories, activity, or hydration
• Routine mastery: The more consistent your day-to-day, the better the results
• Engagement: patients engaging with the Medicspot behaviour change course and weekly whatsapp check-ins with a Medicspot Health Coach generally see more effective weight loss.

Want to make the most of your first 4 months on Mounjaro? Here are some actionable tips:

• Keep your “why” in focus; motivation naturally dips
• Mix up meals to avoid diet boredom
• Stay consistent with movement (even low-impact counts)
• Reflect on wins beyond the scale (energy, mood, control)
• Consider goal tracking apps or group accountability

We analyzed data from patients after their fifth month (20 weekly doses) of Mounjaro. Here’s what we found:

• Dose = most commonly 7.5mg or 10mg
• Sample size: 1029 patients
• Average weight loss after 2 months (all patients) = 12.5kg (27.6lbs)

Weight loss continued for the majority, though a few experienced plateaus. These are often overcome through routine adjustments or dose evaluation.

Mounjaro Month 5 Insights and Tips

Progress continues in month 5 (weeks 16 to 20), and may be shaped by:

• Dose stability: 10 mg tends to show the strongest appetite control
• Mental fatigue: It’s normal to feel less excited—structure helps
• Plateau phases: Reassess calories, activity, or hydration
• Routine mastery: The more consistent your day-to-day, the better the results
• Engagement: patients engaging with the Medicspot behaviour change course and weekly whatsapp check-ins with a Medicspot Health Coach generally see more effective weight loss.

Want to make the most of your first 5 months on Mounjaro? Here are some actionable tips:

• Celebrate non-scale victories (NSVs): clothing fit, energy, strength
• Add variety to meals and movement to prevent boredom
• Lean into community or professional coaching if motivation dips
• Revisit your goals monthly
• Start preparing for maintenance mode if you are nearing your goal weight: what does sustainability look like for you?

We analyzed data from patients after their sixth month (24 weekly doses) of Mounjaro. Here’s what we found:

• Dose = most commonly 10mg, 12.5mg or 15mg
• Sample size: 1029 patients
• Average weight loss after 6 months (all patients) = 14.2kg (31.3lbs)

Weight loss continued for the majority, though a few experienced plateaus. These are often overcome through routine adjustments or dose evaluation.

Mounjaro Month 6 Insights and Tips

Progress continues in month 6 (weeks 21 to 24), and may be shaped by:

• Dose optimization: higher doses help overcome plateaus, but require tolerance
• Psychological shifts: patients report fewer binge cycles and greater mindfulness
• Routine mastery: most patients have found a rhythm that works long term
• Support and accountability: external motivation (coaches, groups) continues to make a difference
• Engagement: related to the point above, patients engaging with the Medicspot behaviour change course and weekly whatsapp check-ins with a Medicspot Health Coach generally see more effective weight loss.

Want to make the most of your first 6 months on Mounjaro? Here are some actionable tips:

• Reflect on your non-weight-related victories, such as confidence, habits, mental clarity
• Explore new physical activities or fitness goals
• Begin maintenance planning if weight loss slows
• Use journaling to track changes in hunger, mood, and lifestyle
• Reconnect with your original motivation (and update it if needed)

“I’ve struggled with my weight most of my adult life and now I’ve finally found something that actually works.

It’s really suppressed my appetite and in doing so has made me make some really healthy choices. It just comes so naturally to me now to go for the healthier option over the unhealthy option.

Also I’m not really finishing as much on my plate anymore and I just feel so much healthier and more energetic and I just feel really positive about the future.”

“”Bit of a NSV victory today. I weighed in and within 23 weeks I am within the healthy BMI bracket! I can’t believe it! I have gone from a BMI of 34.7 to 24.9!! My life has really changed”

Mounjaro begins affecting appetite relatively early in treatment, but visible results usually take longer.

Typical sequence:

• Weeks 1 to 3: subtle changes in appetite and fullness for many people, as the body adjusts to the medicine
• Weeks 4 to 8: more noticeable changes in eating habits and early weight loss for a large number of users
• Weeks 8 to 16: clearer physical changes in body shape and clothing size

The medicine tends to become more effective for weight loss as doses increase and as consistent habits build around food, activity and sleep.

Your results will not be identical to those in clinical trials. Important influences include:

• Starting weight and body composition
• Underlying health conditions such as type 2 diabetes, fatty liver disease or sleep apnoea
• The maximum dose you reach and how long you stay on it
• Whether you need dose reductions or pauses because of side effects
• The type and amount of food you eat and how regularly you eat
• Levels of physical activity, including both structured exercise and daily movement
• Sleep quality, stress and emotional health
• Other medicines you take which may affect weight

Weight loss with Mounjaro rarely follows a perfectly straight downward line. It is common to see periods of quicker progress followed by plateaus or small temporary increases.

Plateaus can happen when:

• Your body adjusts to a lower weight and a new energy balance
• Activity levels change
• Sleep or stress patterns are disturbed
• Hormonal cycles vary

Short term plateaus do not mean the treatment has stopped working. In many cases, results resume once lifestyle factors are addressed or the dose is adjusted, if appropriate. For more information see our article on Overcoming Plateaus.

It is important to recognise that weight regain is likely if treatment is stopped and the underlying drivers of weight gain are not addressed. Studies of tirzepatide and other weight loss medicines show a tendency for weight to return when treatment is withdrawn, highlighting the need for long term strategies.

Both Mounjaro and Wegovy are weekly injections used for weight management, but they contain different active ingredients and work in slightly different ways. Wegovy contains the GLP-1 receptor agonist semaglutide. Mounjaro contains tirzepatide, which acts on both GIP and GLP-1 receptors.

Head to head trials suggest that tirzepatide can lead to greater average weight loss than semaglutide in some settings, although the best choice of treatment depends on individual factors, tolerability and clinical judgement.

This comparison is for general information only and is not intended to recommend one treatment over another. For more information see our in-depth article comparing Mounjaro and Wegovy.

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other healthcare professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire alongside other independently validated medical information about you and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases, the clinicians may contact you for additional information. See Terms of Service for more information.