Side Effects Coming Off Mounjaro

One of the biggest challenges when coming off Mounjaro is increased hunger. Since Mounjaro’s active ingredient (tirzepatide) helps regulate hunger hormones¹, stopping it can lead to a rise in cravings and a stronger appetite, making it harder to maintain weight loss. Some people also experience rapid weight regain², particularly if they don’t adjust their diet after stopping.

Mounjaro slows down digestion, which helps you feel fuller for longer. After stopping the medication, your digestive system may adjust in the following ways:

• Increased hunger and faster digestion
• Bloating or gas due to dietary changes
• Mild nausea or stomach discomfort as the gut readjusts

Some people feel tired or sluggish after stopping Mounjaro. This can happen because:

• Your body is no longer receiving the appetite-regulating effects of the medication.
• Changes in eating habits can lead to energy fluctuations.
• Metabolism shifts may impact how efficiently your body burns calories.

Since Mounjaro helps control appetite and cravings, stopping it can lead to stronger urges for high-calorie, high-carb, or sugary foods. Some people also experience mood swings, frustration, or irritability, particularly if they relied on Mounjaro to manage emotional eating.

While starting Mounjaro often causes nausea or digestive issues, stopping it can also trigger temporary stomach discomfort as your gut adjusts. Some people report:

• Diarrhea or loose stools
• Constipation
• Mild stomach cramps

If you’re planning to stop Mounjaro, it’s best to do so gradually and with a plan in place. Here’s some advice for coming off the medication while maintaining weight loss:

• continue healthy eating habits – stick to a well-balanced diet to avoid rapid weight regain.
• stay hydrated – proper hydration supports digestion and energy levels.
• increase physical activity – regular movement can help stabilise metabolism and energy levels.
• monitor appetite changes – be mindful of cravings and plan meals in advance to stay in control.
• seek medical advice – if you experience Mounjaro side effects, speak to your prescriber.

Coming off Mounjaro is a major milestone, but it doesn’t mean your journey ends here. The habits you build now will determine whether your progress lasts.

Focus on consistency over perfection – eat balanced meals, move regularly, sleep well, and check in with your aftercare team if anything feels off.

If you’re not sure when or how to stop safely, our clinical team can help you build a tapering and aftercare plan that fits your goals.

¹ Electronic Medicines Compendium (EMC). Mounjaro KwikPen 2.5mg solution for injection in pre-filled pen – Summary of Product Characteristics (SmPC). Last accessed November 2025. [https://www.medicines.org.uk/emc/product/15481/smpc]

² Wilding, J.P.H. et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes, Obesity and Metabolism (2022). Last accessed November 2025. [URL: https://pubmed.ncbi.nlm.nih.gov/35441470/]

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases the clinicians may contact you for additional information. See our Terms of Service for more information.