Wegovy Results Timeline

If you’ve decided to begin treatment with the GLP-1 receptor agonist Wegovy (semaglutide) for weight management, you’re likely asking:

• “When will I see results?”
• “What will change each month?”

At Medicspot, we know this journey can feel both hopeful and a little uncertain.

That’s why our care is clinically supervised – a prescribing pharmacist reviews each case for appropriateness, and we’ll verify your medical history using your NHS Summary Care Record (SCR). Your health coach will monitor your progress and support you every step of the way.

Wegovy belongs to the class of GLP-1 (glucagon-like peptide-1) receptor agonists. These medications mimic a natural hormone that regulates appetite and blood sugar. Here’s what you might experience:

• You start feeling fuller sooner and for longer after meals.¹
• You experience fewer hunger spikes and reduced food cravings.²
• Combined with a calorie-reduced diet and increased physical activity, the medication supports meaningful weight loss over time.

The first months on Wegovy are about building the foundation – adjusting your dose, adapting your routine, changing eating habits – rather than expecting dramatic results overnight.

Wegovy results after 1 month

During your first 4 weeks on Wegovy, weight loss is often modest. Some people notice the scales begin to move, others mainly notice appetite changes. Both are normal at this stage.

Why month 1 matters

Month 1 is about adaptation. Your body is getting used to the medication dose, and your routine (diet, movement, check-ins) is being established. Your appetite may decrease and you might feel less tempted to snack.

Key tips for this phase

• Track how your appetite and cravings are changing rather than focusing purely on the number on the scale.
• Respond to your check-ins with your health coach or prescriber. Any side effects (i.e. nausea, digestion changes) should be reviewed quickly.
• Continue with a reduced-calorie plan and aim to maintain or gently increase physical activity as tolerated.
• Recognise that small changes this month build toward bigger ones later.

Wegovy results after 2 months

Around weeks 5 to 8:

• The fullness effect of the medication becomes more consistent.
• You may start to notice your weight loss increasing.
• You might notice slight changes in waist size or how clothes fit.

Why month 2 matters

By month 2, the medication’s appetite regulating effects and your growing habit changes are beginning to take effect.

Key tips for this phase

• Review your food choices with your health coach. Identify one snack swap or portion adjustment you can make.
• Gradually increase your incidental movement (walking, standing breaks) if medically appropriate.
• If you’re not seeing much change yet, don’t worry – consistency counts more than speed.
• Celebrate even small wins, like feeling less hungry, getting through a full day without craving, fitting into an old outfit.

Wegovy results after 3 months and 4 months

During months 3 and 4 (weeks 9-16):

• Appetite control and fullness become more consistent and less variable.
• Weight loss may accelerate. Real-world data show ~5.9% weight loss at 3 months and ~10.9% at 6 months in one cohort study.³
• Clothes may feel visibly looser. You might get feedback from others or notice changes in your own confidence.
• The routine of new eating and movement habits becomes more embedded.

Why this matters

This phase is where momentum builds. The medication plus your new habits start to combine so that change becomes more evident and sustainable.

Key tips for this phase

• Look for non-scale victories, such as improved energy, better sleep, improved mood or motivation.
• If you plateau or slow down, talk to your Medicspot coach about habits rather than quick-fix changes.
• Use this momentum to strengthen new routines, like regular meals, scheduled movement, and consistent check-ins.

What you might notice

Around weeks 17-24:

• Appetite and fullness regulation are well established.
• Weight loss may continue steadily – some patients might see Wegovy results after 6 months of ~10% weight loss or more of starting body weight.³
• Your behaviour changes may now feel more like part of your “normal routine” rather than a new effort.
• You might start shifting your focus from “making changes” to “maintaining change”.

Why this matters

Month 6 is a milestone. You’ve passed beyond the initial adaptation phase and are now in the ‘progress and habit’ phase.

But one review showed that stopping semaglutide led to weight regain of ~11.6% on average between weeks 68 and 120.⁴ This emphasises why maintaining new habits and continuity support matters.

Key tips for this phase

• Have your Medicspot coach review what has worked and what hasn’t. Set a medium-term goal for the next 3-6 months.
• Begin thinking about your ‘maintenance strategy’ – how these new habits can become long-term rather than short-term.
• Understand that while early progress is great, staying the course and embedding change bring long-term benefit.

Your results on Wegovy will depend on many factors: your starting weight or BMI, whether you have type 2 diabetes, how consistent you are with medication and lifestyle support, your age, and your individual metabolism.

For example, in the STEP trials for semaglutide 2.4mg, participants without diabetes lost on average ~14.9-17.4% of body weight at 68 weeks.²

• Be consistent with your weekly dose and attend your scheduled check-ins with your health coach.
• Stick with a reduced-calorie diet and physical activity plan. Medication is a powerful aid, but it’s not a stand-alone solution.
• Use your Medicspot health coach – regular check-ins help you embed habits and manage side effects.
• Monitor side effects and report any concerns early.
• Set realistic expectations – losing ~5-10% of your starting weight by month 6 is a fantastic outcome. Further loss might follow depending on your circumstances.

By month 6 you’re well into the routine and change phase. However, long-term data shows continuing medication and lifestyle support are key.

For example, in one extension study of semaglutide, stopping treatment led to significant weight regain of ~11.6%.⁴

At Medicspot:

• Your health coach tracks your progress and helps you turn new habits into lasting routines.
• Your prescriber reviews your treatment for ongoing safety and suitability.
• Together, we’ll focus on maintaining results and supporting your long-term goals.

Wegovy is just one part of your journey. The real change comes from the routines, mindset, and support you develop along the way.

At Medicspot, our team of clinicians and health coaches are here to help you keep that momentum going – safely, confidently, and sustainably.

Whether you’re just starting or already seeing results, we’re here to help.

¹ British Heart Foundation. Wegovy: What you need to know about the weight-loss injection. Last accessed October 2025. [https://www.bhf.org.uk/informationsupport/heart-matters-magazine/medical/ask-the-experts/wegovy]

² Wilding, J.P.H. et al. Semaglutide for the treatment of overweight and obesity: A review. Diabetes, Obesity and Metabolism (2023). Last accessed October 2025. [https://pmc.ncbi.nlm.nih.gov/articles/PMC10092086/]

³ JAMA Network Open. Weight Loss Outcomes Associated With Semaglutide Treatment for Obesity (2022). Last accessed October 2025. [https://pmc.ncbi.nlm.nih.gov/articles/PMC9486455/]

⁴ Wilding, J.P.H., Batterham, R.L., Davies, M., et al. “Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension.” Diabetes, Obesity and Metabolism, 2022; 24(8): 1553-1564. Last accessed October 2025. [https://pmc.ncbi.nlm.nih.gov/articles/PMC9542252/]

NHS England. Weight-management medicines (GLP-1 receptor agonists) for obesity. Last accessed October 2025. [https://www.england.nhs.uk/ourwork/prevention/obesity/medicines-for-obesity/]

New England Journal of Medicine. “STEP 1 Trial Summary. Once-weekly semaglutide in adults with overweight or obesity.” (2021). Last accessed October 2025. [https://www.nejm.org/doi/full/10.1056/NEJMoa2032183]

Diabetes UK. Wegovy and GLP-1 medications – how they help with weight loss.
Last accessed October 2025. [https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/tablets-and-medication/glp-1/semaglutide/wegovy]

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases the clinicians may contact you for additional information. See our Terms of Service for more information.