Wegovy 1mg Dose Guide

Feeling ready for the next step

You’ve made it to 0.5mg – that’s a big milestone. It’s normal to feel both proud and a little unsure about moving up to the 1mg Wegovy dose. This next stage is about building on what you’ve already achieved. For many people, your body’s adapting, your appetite is settling, and you’re getting closer to where the real progress begins.

What the 1mg Wegovy dose means

Wegovy (semaglutide) is a weekly, clinician-supervised treatment from a class of medicines called GLP-1 receptor agonists, which mimic a natural hormone that helps control appetite and blood sugar.¹ The 1mg dose is usually introduced once you’ve tolerated the lower doses and your clinician is happy with how you’re responding. It’s a sign that your plan is working, and that your body’s ready for the next step.

Who Wegovy is licensed for in the UK

In the UK, Wegovy is licensed for adults with a BMI of 30kg/m² or higher, or 27kg/m² or higher if you have a weight-related condition such as high blood pressure, high cholesterol, or sleep apnoea.²

Your journey with Wegovy is planned in steps. It starts low, then builds up to your maintenance dose. Typical dose escalation might look like: 0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg maintenance dose.³ The 1mg mark is often around weeks 9-12 of this schedule. It’s a time when your body has had a chance to adjust and you’re ready for a higher dose.

This calculator uses data from a major clinical study on GLP-1 weight loss treatment to show what typical progress looks like. Your results will depend on your specific medication, dose, lifestyle, and medical history.

Every person’s journey is unique. You may stay at 1mg if:

• side effects are still present and you need more time,
• you are progressing well in weight and appetite control, and your clinician decides further escalation may come later,
• you have co-morbidities or other health issues requiring slower titration.

The aim always is safe, effective, sustainable weight management, not simply chasing a number.

Effects on appetite and metabolism

Now that you’re at 1mg, many people begin to notice more stable changes: less frequent hunger, smaller portion sizes, fewer snacks. For some members, cravings shrink, and fullness sets in sooner. While the full maintenance effect may not yet be reached, this dose is still meaningful.

Clinical data show that at higher doses (e.g. 2.4mg) semaglutide has led to average weight losses around 15% of body weight in trials for people without diabetes.⁴ While you are not at that maintenance dose yet, you’re moving in that direction.

Monitoring your progress

You may want to consider tracking:

• how your hunger feels (are you more in control?)
• what your portion sizes look like
• weight and waist measurements week by week
• how you feel after meals, including energy levels and mood
• any side effects or unexpected symptoms

Because GLP-1 receptor agonists like semaglutide can slow stomach emptying and affect gut signalling, you may experience side effects, such as:

• Nausea or vomiting
• Diarrhoea or constipation
• Bloating or mild tummy discomfort
• Reduced tolerance for large meals
• Potential dehydration if vomiting or diarrhoea cause fluid loss.

• Eat smaller, more frequent meals rather than 3 large meals.
• Choose nutrient-dense, high-fibre foods that promote fullness (vegetables, whole grains, lean protein).
• Stay well-hydrated – drink 6 to 8 cups or glasses of fluid a day unless restricted.
• Avoid particularly fatty or heavy meals during adjustment weeks.
• Notify your prescriber if you experience persistent or severe vomiting, dehydration, or unexplained abdominal pain (which could signal pancreatitis).
• If side effects persist, your Medicspot team may hold the 1mg dose for additional weeks before titration.

What to look out for

Mild side effects are normal and to be expected. If you feel your symptoms are more severe than you expected or you are concerned please us.

We would always want to know about stomach pains that feel a little more than a mild discomfort or if you start feeling unwell. Any unusual redness or discharge from your injection site is also something to look out for.

You’ve built the foundation, got through the early adjustment weeks, and now you’re stepping into the next phase.

The Wegovy 1mg dose is a sign of progress. Your body is adjusting, your appetite is stabilising, and you’re learning how to make these changes part of everyday life.

Think of this phase as building strength for the long run – not just losing weight, but gaining control, confidence, and consistency that lasts.

¹ European Medicines Agency (EMA). Wegovy (semaglutide) – summary of product characteristics. Last accessed October 2025. [https://www.ema.europa.eu/en/medicines/human/EPAR/wegovy]

² NICE. Semaglutide for managing overweight and obesity (2023). Last accessed October 2025. [https://www.nice.org.uk/guidance/ta875]

³ European Medicines Agency (EMA). Wegovy (semaglutide): Summary of Product Characteristics. Last accessed October 2025. [https://www.ema.europa.eu/en/documents/product-information/wegovy-epar-product-information_en.pdf]

⁴ New England Journal of Medicine. “STEP 1 Trial Summary. Once-weekly semaglutide in adults with overweight or obesity.” (2021). Last accessed October 2025. [https://www.nejm.org/doi/full/10.1056/NEJMoa2032183]

Wegovy. Wegovy dosing schedule. Last accessed October 2025. [https://www.wegovy.com/taking-wegovy/dosing-schedule.html]

Diabetes UK. Wegovy and GLP-1 medications – how they help with weight loss. Last accessed October 2025. [https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/tablets-and-medication/glp-1/semaglutide/wegovy]

NHS England. Weight-management injections. Last accessed October 2025. [https://www.england.nhs.uk/ourwork/prevention/obesity/medicines-for-obesity/weight-management-injections/]

GOV.UK. GLP-1 receptor agonists: reminder of the potential side-effects and misuse risk. UK Drug Safety Update (2023). Last accessed October 2025. [https://www.gov.uk/drug-safety-update/glp-1-receptor-agonists-reminder-of-the-potential-side-effects-and-to-be-aware-of-the-potential-for-misuse]

Medicines.org.uk. Wegovy patient information leaflet. Last accessed October 2025. [https://www.medicines.org.uk/emc/product/13800/pil]

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases the clinicians may contact you for additional information. See our Terms of Service for more information.