Mounjaro 2.5mg Dose Guide

Mounjaro 2.5mg (tirzepatide) is the starting point of the dose-escalation schedule. It is not intended to produce significant weight loss. Instead, it is used to:

• allow your body to adapt gradually
• reduce the likelihood of early side effects
• prepare you for later therapeutic doses (5mg and above)

Most people remain on 2.5mg for four weeks before moving up.

Because 2.5mg is a non-therapeutic dose, early effects are usually subtle. Common experiences include:

• mild appetite changes
• feeling full slightly sooner than usual
• occasional nausea or bloating
• fluctuations in energy levels

These effects vary widely and often settle as your body adapts.

Most people tolerate the starting dose well. You may experience:

• nausea
• bloating or constipation
• tiredness
• headaches

These symptoms are typically temporary and improve within one to two weeks. Eating smaller meals, reducing high-fat foods, and staying well hydrated can help. If symptoms are persistent or severe, speak to a clinician.

Week 1
You may notice little or no appetite change at first.

Weeks 2–3
Mild digestive symptoms can appear as your body adjusts.

Week 4
A clinician will usually review your progress and discuss whether you’re ready to increase to 5mg.

Most people begin to experience more meaningful effects after moving beyond 2.5mg.

The standard titration schedule moves from 2.5mg to 5mg after four weeks. A clinician will consider:

• how well you tolerated the starting dose
• any side effects you experienced
• whether the early response suggests readiness for the next step

If symptoms took longer to settle, you may be advised to stay on 2.5mg slightly longer before increasing.

Although 2.5mg is primarily a starting dose, some people return to it temporarily:

• If side effects occur at higher doses
A short step down can allow symptoms to settle before resuming titration.

• When tapering off treatment
A lower dose may be used as part of a planned transition under clinical supervision.

These adjustments are always made by a clinician based on your response and overall health.

Mounjaro is taken once weekly as a subcutaneous injection.

General guidance includes:

• choose a consistent day each week
• rotate injection sites (abdomen, thigh, or upper arm)
• it can be taken with or without food

Always follow the instructions provided with your medication.

• Keep refrigerated between 2–8°C
• Do not freeze
• If needed, it can be kept at room temperature (up to 30°C) for up to 30 days
• Avoid sunlight and heat
• Do not use after the expiry date
• Always use a new needle for each injection

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases the clinicians may contact you for additional information. See our Terms of Service for more information.