Mounjaro 7.5mg Dose Guide

The Mounjaro 7.5mg injection is typically the third step in a titration protocol once the 5mg dose has been tolerated well and weight loss or appetite suppression has plateaued.

It may be considered when the 5mg dose is no longer delivering sufficient effect, or when your physiological response suggests you could benefit from a stronger dose.

For example, if your weight loss has slowed after 4-8 weeks on 5mg, if your appetite suppression is less consistent, or if you are clinically advised that a higher dose is appropriate.

At Medicspot, a 4-week supply of Mounjaro 7.5mg costs £269. This is a private patient price that includes the medication, clinical oversight, and ongoing coaching and support as part of our weight management programme.

Mounjaro is not yet widely available on the NHS for weight loss, and NHS eligibility criteria are still being rolled out following NICE guidance¹. Access is being phased in over three years for prioritised groups of people depending on certain medical conditions and criteria – availability varies by area, so most patients in the UK currently access Mounjaro through private providers like Medicspot.

Prices may vary slightly between clinics depending on dispensing costs and service inclusions, but all UK-supplied pens are MHRA-licensed and come from regulated pharmacies.

If you’re already using Mounjaro, you can switch to Medicspot by sharing proof of your current prescription:

• A copy of your existing prescription, or
• An invoice from your current weight loss provider.

Benefits of the 7.5mg pen may include:

• Stronger appetite suppression – you may notice fewer cravings and feel fuller for longer.
• More pronounced weight loss – when combined with diet and exercise, weight loss may accelerate.
• Improved metabolic effects – including improved insulin sensitivity and better blood glucose control².
• Slower gastric emptying – you may feel full faster than normal³. This can also affect absorption of some oral medicines.

Common Mounjaro side effects may include:

• Nausea – this is more likely during the adjustment phase, often easing within 1-2 weeks.
• Fatigue or low-energy – especially as appetite falls and caloric intake may reduce.
• Digestive changes – including mild constipation or bloating⁴.
• Injection site reactions – redness, itching or discomfort may occur as you switch pens or dose.

At this dose your dual GIP/GLP-1 agonist therapy (tirzepatide) is working harder: it enhances appetite suppression, slows gastric emptying and improves insulin sensitivity.

You may feel fuller for longer, notice reduced hunger between meals and potentially see faster or greater weight loss than at lower doses. As your body adapts, portion sizes may reduce naturally, and you may require fewer snacks or less frequent urges to eat.

Your metabolic profile may continue to improve. Many patients at higher doses show better glucose control and reduced insulin resistance when combined with lifestyle change.

These testimonials highlight the varying experiences of real users – some tolerate the 7.5mg pen immediately, others need a few weeks of adjustment for side effects to subside.

Please remember, each individual responds differently to the medication, and your journey may differ to other people’s experiences.

“I’m currently on 7.5, I’ve not had much side effects so I’ve increased the dose every month.”

“Steady loss on 7.5”

“I stuck to 5 for 3 months but I’m now on 7.5 and so far no adverse reactions.”

“I’ve been on 7.5 for two weeks had side effects of aching and nausea after eating. But suppression is excellent.”

 

Consider stepping up to 7.5mg if you meet all of the following:

• You have been on the 5mg dose for at least 4 weeks (or as advised).
• Appetite suppression is fading or inconsistent before your next injection.
• Weight loss on 5mg has slowed or plateaued despite consistent lifestyle support (diet, activity).
• You are not experiencing significant side effects at the 5mg dose.

However, you might need to pause or reduce if:

• You are experiencing significant side effects at 7.5mg.
• You have reached your healthy target weight and wish to maintain rather than continue rapid loss.
• You have developed nutritional deficiencies, intolerances, or other medical concerns requiring review.

• Don’t ignore side effects – If nausea or fatigue are affecting your daily life, it’s important to scale back to 5mg or speak with your clinician about ways to manage them.
• Don’t rush to 10mg – If you’re still adjusting at 7.5mg, give your body more time. It’s common for results to improve steadily over the course of a few weeks.
• Don’t skip meals – At 7.5mg, appetite suppression can be strong, but it’s still important to eat regular meals to maintain energy levels and avoid nutrient deficiencies.

The Mounjaro 7.5mg injection is an important step in your titration journey, helping your body continue adapting and supporting steady, sustainable weight loss.

Take time to listen to your body, maintain good hydration, eat balanced meals with enough protein, and stay consistent with your healthy habits. Weight loss is most sustainable when medication works alongside lifestyle changes, not instead of them.

If you’re unsure whether to stay at 7.5mg or move to the next dose, speak with your clinician. They can help you decide what’s right for your goals, ensuring you progress safely and confidently.

Dr Jackir Hussain is a GP with over 14 years of experience, having earned his medical degree from the University of Manchester. He has worked across a wide range of primary care settings, including NHS surgeries, unscheduled care services, homeless shelters, and telemedicine. Dr Hussain is passionate about delivering accessible, patient-centred care and helping individuals take practical steps toward improving their health. In his role at Medicspot, he brings a wealth of frontline experience and a calm, compassionate approach to supporting patients on their weight management journey.

Dr Abby Hyams grew up in Manchester and completed her medical training in Bristol. She has been a GP for 19 years, spending many of those as a partner in an NHS practice in Hemel Hempstead. Dr Hyams loves being a GP because of the wide spectrum of people she encounters every day and the opportunity to make a meaningful difference in their lives. She has a particular passion for supporting patients with weight loss and promoting positive behaviour change, helping individuals build sustainable habits that improve their long-term health and wellbeing.

¹ National Institute for Health and Care Excellence (NICE). “NICE describes how weight loss drug tirzepatide will be rolled out.” News article, 5 December 2024. Last accessed November 2025. [https://www.nice.org.uk/news/articles/nice-describes-how-weight-loss-drug-tirzepatide-will-be-rolled-out]

² National Institute for Health and Care Excellence (NICE). Tirzepatide for managing overweight and obesity (Technology appraisal guidance TA1026). Published 23 Dec 2024. Last accessed November 2025. [https://www.nice.org.uk/guidance/ta1026/chapter/1-Recommendations]

Eli Lilly and Company Ltd. “Mounjaro® KwikPen 7.5 mg solution for injection in pre-filled pen – Summary of Product Characteristics (SmPC).” Electronic Medicines Compendium (eMC). Last accessed November 2025. [https://www.medicines.org.uk/emc/product/15483/smpc]

Diabetes UK. Mounjaro (tirzepatide) – uses, how it works and side effects. Last accessed November 2025. [https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/tablets-and-medication/glp-1/mounjaro]

Wilding JPH et al. “Tirzepatide once weekly for the treatment of obesity.” New England Journal of Medicine. 2022; 387(18): 1713–1724. DOI: 10.1056/NEJMoa2206038. Last accessed November 2025. [https://www.nejm.org/doi/full/10.1056/NEJMoa2206038]

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases the clinicians may contact you for additional information. See our Terms of Service for more information.