How To Come Off Mounjaro Safely

The process of coming off Mounjaro – often called tapering off or weaning off Mounjaro – works best when it’s done with clinical guidance and consistent support.

• Don’t stop Mounjaro suddenly – taper gradually to give your body time to adjust.
• Get clinical guidance before reducing your dose to ensure it’s safe and effective.
• Maintain healthy habits like balanced eating and regular activity to prevent weight regain.
• Get ongoing support and coaching help you stay in control and maintain your results long term.

Coming off Mounjaro doesn’t mean going it alone.

Our clinical and coaching team will guide you through every stage of your taper – helping you manage appetite changes, prevent weight regain, and adjust your plan when needed.

If you experience increased hunger or notice your weight creeping up, you’ll receive personalised advice from our clinicians and health coaches to stay on track.

You’ll also get access to our private WhatsApp support group, where members share tips, progress, and motivation. You can ask questions, get reassurance, or simply read advice from others who understand the journey.

Our goal isn’t just to help you come off Mounjaro – it’s to help you maintain your success.

With weekly check-ins, our Essential Nutrition Course, and long-term maintenance coaching, you’ll build sustainable habits that support lasting weight management and confidence.

According to NICE guidance on tirzepatide (Mounjaro)¹, treatment should be regularly reviewed and is usually continued only while it leads to meaningful weight loss and health benefits.Clinicians are advised to discuss how long treatment might continue and when to reduce your Mounjaro dose, including the plan for stopping.

If you want to switch to Medicspot, simply complete our free online assessment to see if tapering is right for you.

Our UK-registered clinicians will review your answers and your NHS Summary Care Record to confirm that reducing your dose is safe and appropriate before prescribing.

A gradual approach helps your body adapt and reduces the risk of appetite rebound. Many clinicians use a practical approach of reducing by 2.5mg roughly every 4 weeks, mirroring the way tirzepatide doses are increased.

Your exact plan should be tailored to your symptoms, weight trend, and side effects. At Medicspot, you’ll receive ongoing check-ins with your dedicated health coach and get support from our clinical team to ensure you feel confident at every stage.

As you wean off Mounjaro, you’ll continue to receive weekly contact from your Medicspot health coach, plus full access to our Essential Nutrition Course. These resources focus on meal planning, managing hunger cues, and maintaining new habits and activity – key factors in sustaining your results once injections stop.

You’ll also receive 12 months of free aftercare once your medication ends, including behavioural support, nutrition guidance, and relapse-prevention coaching.

NICE highlights that people stopping weight management medicines should receive advice and support for at least a year to help keep the weight off².

Weaning off Mounjaro step by step gives your body time to adjust, helping to keep your appetite stable and your weight steady. Our clinicians will guide you through reducing your Mounjaro dose – from higher doses like 15mg down to 2.5mg – with weekly check-ins and nutrition support to make the process simple and sustainable.

Pricing by 4 week supply:

• Mounjaro 15mg – £329
• Mounjaro 12.5mg – £309
• Mounjaro 10mg – £289
• Mounjaro 7.5mg – £269
• Mounjaro 5mg – £219
• Mounjaro 2.5mg – £199

Each plan includes:

• Free delivery and full clinical review before each reduced dose
• Regular health coach check-ins to guide you through reducing your dose of Mounjaro
• Access to our Essential Nutrition Course for meal planning, motivation, and building lasting habits
• 12 months of free aftercare once you’ve finished treatment, helping you maintain your results, manage appetite, and feel confident after the medication

The goal isn’t to rush the process, but to make sure your appetite, confidence, and habits remain steady as your Mounjaro dose comes down.

By tapering gradually and staying connected with your clinical and coaching team, you give yourself the best chance of maintaining the progress you’ve worked hard for.

Every person’s journey is slightly different, so take it step by step, listen to your body, and use the support available to you.

¹ National Institute for Health and Care Excellence (NICE). Overweight and obesity: pharmacological management (NG246). London: NICE; 2023. Last accessed November 2025. [https://www.nice.org.uk/guidance/ng246]

² National Institute for Health and Care Excellence (NICE). People need support to keep weight off after treatment ends. News article (2025). Last accessed November 2025. [https://www.nice.org.uk/news/articles/people-need-support-to-keep-weight-off-after-treatment-ends]

³ Wilding, J.P.H. et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension. Diabetes, Obesity and Metabolism (2022). Last accessed November 2025. [https://pubmed.ncbi.nlm.nih.gov/35441470/]

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases the clinicians may contact you for additional information. See our Terms of Service for more information.